There are injury concerns over Adam Lallana who injured his groin playing for England and is a major doubt to face his former club.
Phil Coutinho is also a worry as he was pictured leaving Hospital in Liverpool on Thursday evening for a scan on a tight hamstring while playing for his native Brazil.
If both players fail to make it, then Manager Jurgen Klopp will have a number of decisions to make.
Maybe Wijnaldum in for Lallana and Sturridge to start up front with Firmino and Mané around him.
Possible Liverpool team:
We should be in for an entertaining encounter at The Dell, as they used to call it, with Southampton lying in 10th position under Claude Puel, they like to play good football and so do we.
Expect Liverpool to earn another three points away from home by at least two clear goals.